Schizophrenia, corpus callosum, and interhemispheric communication: a review

The literature suggests that some schizophrenic patients may have a dysfunction in the transfer of information between the two cerebral hemispheres via the corpus callosum (CC). The presence of an abnormally thickened CC in some schizophrenic patients and an abnormally thin CC in others suggests a possible anatomic basis for abnormal organization of cognitive functions in these patients resulting from either increased or decreased communication between the two cerebral hemispheres. The findings of the anatomic studies have suggested a connection between a thickened CC and both early onset and negative symptom patterns in schizophrenic patients. Similarly, onset of symptoms later in life and positive symptom patterns have been associated with a thinner CC. Behavioral and electrophysiological findings appear to support the idea that the same subgroups may be associated with opposite patterns of effective transfer of information between the cerebral hemispheres. Careful analysis of the transfer of information between the cerebral hemispheres for selected groups of schizophrenic patients and normal controls could provide important information about cerebral organization and possible mechanisms operative in schizophrenia.