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Published on: September 11, 2019
Urinary NGAL marks cystic disease in HIV-associated nephropathy
Neal Paragas1, Thomas L Nickolas, Christina Wyatt
1College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
Journal of the American Society of Nephrology : JASN
|July 25, 2009
Summary
Urinary neutrophil gelatinase-associated lipocalin (NGAL) is significantly elevated in HIV-associated nephropathy (HIVAN). This finding suggests urinary NGAL may help noninvasively diagnose HIVAN and tubular damage.
Area of Science:
- Nephrology
- Biomarker Discovery
- Virology
Background:
- HIV-associated nephropathy (HIVAN) presents as nephrosis and rapid kidney function decline.
- Histologically, HIVAN involves collapsing focal segmental glomerulosclerosis and significant tubular damage.
Purpose of the Study:
- To investigate urinary neutrophil gelatinase-associated lipocalin (NGAL) as a potential noninvasive diagnostic marker for HIVAN.
- To assess the correlation between NGAL expression and tubular injury in HIVAN.
Main Methods:
- Measured urinary NGAL levels in patients with biopsy-proven HIVAN, HIV-positive controls, and HIV-negative controls with other chronic kidney diseases.
- Examined NGAL mRNA expression in an HIV-transgenic mouse model of HIVAN.
- Assessed the relationship between urinary NGAL and proteinuria in both human and mouse models.
Main Results:
- Urinary NGAL levels were significantly higher in patients with HIVAN compared to control groups.
- NGAL mRNA was notably abundant in damaged nephron segments within the HIVAN mouse model.
- Urinary NGAL levels did not correlate with proteinuria in humans or mice.
Conclusions:
- Marked upregulation of NGAL is associated with HIVAN.
- Urinary NGAL shows promise as a noninvasive biomarker for HIVAN diagnosis.
- Further studies are warranted to evaluate uNGAL for screening HIVAN-related tubular damage in larger cohorts.
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