Related Experiment Video
Updated: Jun 21, 2026

Signal Acquisition, Score Interpretation, and Economics of a Non-Invasive Point-of-Care Test for Coronary Artery Disease
Published on: August 9, 2024
Can the ABCD2 risk score predict positive diagnostic testing for emergency department patients admitted for transient
Jon W Schrock1, Aaron Victor, Theodore Losey
1Department of Emergency Medicine, MetroHealth Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH 44109-1998, USA. jschrock@metrohealth.org
Insights
The ABCD2 score, used for transient ischemic attack risk, did not predict positive diagnostic tests in most evaluations. An elevated score may indicate severe carotid disease but is not recommended for guiding acute TIA diagnostic testing.
Area of Science:
- Neurology
- Diagnostic Imaging
- Clinical Risk Stratification
Background:
- Transient ischemic attack (TIA) evaluations require accurate risk stratification.
- The ABCD2 score is a common tool for assessing TIA risk.
- The utility of the ABCD2 score in predicting positive diagnostic test results is not well-established.
Purpose of the Study:
- To determine if the ABCD2 score can predict positive diagnostic test results in patients acutely evaluated for TIA.
- To assess the correlation between elevated ABCD2 scores and findings on various diagnostic tests.
Main Methods:
- Retrospective cohort study of 256 patients with neurologist-confirmed TIA.
- ABCD2 scores were calculated; patients with a score >= 4 were classified as high-risk.
- Evaluated diagnostic tests included ECG, CT, MRI, MR angiography, carotid ultrasonography, and echocardiography.
Main Results:
- 63% of patients had an elevated ABCD2 score (>= 4).
- Diagnostic test completion rates varied significantly by modality.
- An elevated ABCD2 score was significantly associated only with positive carotid duplex testing (P<0.05).
Conclusions:
- An elevated ABCD2 score may predict severe carotid occlusive disease.
- The ABCD2 score does not predict positive outcomes on other commonly ordered TIA diagnostic tests.
- The ABCD2 score is not recommended for guiding diagnostic testing in acute TIA evaluations.
Background And Purpose:
We sought to determine if the ABCD2 score, typically used for risk stratification, could predict having a positive diagnostic test in patients evaluated acutely for transient ischemic attack.
Methods:
We performed a retrospective cohort study for patients admitted from our emergency department with a new diagnosis of transient ischemic attack confirmed by a neurologist. ABCD2 scores were calculated and patients with a score of > or = 4 were placed in the high-risk cohort. Tests evaluated included electrocardiogram, CT, MRI, MR angiography, carotid ultrasonography, and echocardiography. Specific test findings considered to signify positive diagnostic tests were created a priori.
Results:
We identified 256 patients with transient ischemic attack for inclusion; 167 (61%) were female, the median age was 60 years (interquartile range, 50 to 72), and 162 (63%) patients had an ABCD2 score of > or = 4. Rates of completion of diagnostic testing were electrocardiogram, 270 (100%); CT, 224 (88%); MRI, 89 (35%); MR angiography, 68 (27%); carotid ultrasonography, 125 (49%); and echocardiography, 135 (53%). Univariate analysis found a significant association only with elevated ABCD2 score and carotid duplex testing (P<0.05).
Conclusion:
An elevated ABCD2 score may help predict patients with severe carotid occlusive disease but does not predict positive outcome in other commonly ordered tests for patients being evaluated for transient ischemic attack. An elevated ABCD2 score cannot be recommended as a tool to guide diagnostic testing in patients presenting acutely with transient ischemic attack.
Related Concept Videos
Acute Coronary Syndrome III: Diagnostic Studies
Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT
Transient Ischemic Attack l: Introduction
Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation
Acute Coronary Syndrome I: Introduction
