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Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

Oxidative stress and endothelial dysfunction in chronic kidney disease

Valeria Costa-Hong1, Luiz Aparecido Bortolotto, Vanda Jorgetti

  • 1Unidade de Hipertensão, Instituto do Coração, São Paulo, SP, Brasil.

Arquivos Brasileiros De Cardiologia
|July 25, 2009
PubMed

Insights

Oxidative stress is elevated in chronic kidney disease (CKD) patients, correlating with impaired endothelial function. This suggests a link between oxidative stress and endothelial dysfunction, potentially increasing cardiovascular disease risk in CKD.

Area of Science:

  • Nephrology
  • Cardiology
  • Biochemistry

Background:

  • Chronic kidney disease (CKD) is strongly linked to atherosclerosis.
  • Endothelial dysfunction and oxidative stress are known contributors to atherosclerosis.
  • The association between these factors in CKD patients without clinical cardiovascular disease (CVD) requires investigation.

Purpose of the Study:

  • To assess the relationship between oxidative stress and endothelial function in end-stage CKD patients.
  • To determine if oxidative stress is elevated in CKD patients prior to the development of clinical CVD.

Main Methods:

  • A study involving 22 non-diabetic, non-smoking CKD patients on maintenance hemodialysis and 22 healthy controls.
  • Evaluation of endothelium-dependent and independent vascular reactivity.
  • Measurement of oxidative stress via plasma thiobarbituric acid-reactive substances (TBARS) levels.

Main Results:

  • CKD patients exhibited reduced endothelium-dependent and independent vascular reactivity compared to controls.
  • Plasma TBARS levels, an indicator of oxidative stress, were significantly higher in CKD patients.
  • Increased TBARS levels were correlated with reduced endothelium-dependent vascular reactivity and higher systolic blood pressure.

Conclusions:

  • Oxidative stress is elevated in CKD patients even without clinically evident CVD.
  • A significant association exists between increased oxidative stress and endothelial dysfunction in CKD patients.
  • These findings suggest that oxidative stress and endothelial dysfunction contribute to the heightened risk of CVD and its complications in CKD.
Abstract

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