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Relationship between adiponectin and left atrium size in uncomplicated obese patients: adiponectin, a link between

Juan Ybarra1, Eugenia Resmini, Francesc Planas

  • 1Instituto de Cardiología y Medicina Avanzada, Centro Médico Teknon, Barcelona 08017, Spain. JYbarraM@santpau.cat

Obesity Surgery
|July 25, 2009
PubMed

Insights

Lower adiponectin levels are linked to larger left atrial (LA) size in obese individuals, independent of other factors. This suggests adiponectin may influence cardiac remodeling in obesity.

Area of Science:

  • Cardiology
  • Endocrinology
  • Obesity Medicine

Background:

  • Obesity is a significant risk factor for cardiovascular diseases, often associated with left ventricle (LV) and left atrium (LA) enlargement.
  • Factors beyond hemodynamics may contribute to LA remodeling in obese patients.

Purpose of the Study:

  • To investigate the relationship between adiponectin levels and LA size in uncomplicated obese individuals.
  • To explore adiponectin's potential role in cardiac remodeling.

Main Methods:

  • A study involving 74 asymptomatic obese patients and 70 controls.
  • Echocardiographic, clinical, and analytical assessments, including measurement of serum total adiponectin and homeostasis model assessment for insulin resistance (HOMA-IR).

Main Results:

  • Obese individuals exhibited lower adiponectin levels and larger LA sizes compared to controls.
  • Adiponectin levels correlated significantly with various metabolic markers, LV mass, and LA size.
  • An inverse relationship between adiponectin and LA size persisted even after adjusting for HOMA-IR, age, sex, and LV mass.

Conclusions:

  • A novel inverse relationship exists between adiponectin and LA size in obese individuals, independent of age, sex, insulin resistance, and LV mass.
  • Adiponectin may serve as a link between adipose tissue and cardiac remodeling.
Abstract

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