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Updated: Jun 21, 2026
A Rat Lung Transplantation Model of Warm Ischemia/Reperfusion Injury: Optimizations to Improve Outcomes
Published on: October 28, 2021
The potential protective effect of low potassium dextran against lipid peroxidation in a rat lung transplantation
R L Torres1, L K Martins, M Picoral
1Respirology, Porto Alegre General Hospital, 900035-903 Porto Alegre, Brazil.
Abstract:
The overproduction of reactive oxygen species plays an important role in the cascade of events during lung ischemia-reperfusion leading to graft failure. An evaluation of the peripheral markers of oxidative stress and antioxidant enzyme activities was carried out after reperfusion in a rat lung transplant model. The decrease in lipid peroxidation immediately after transplantation ( P < 0.05) may suggest an adaptative response and/or a protective effect of low potassium dextran against lipid peroxidation through natural scavenging mechanisms.
