Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Enoxaparin prophylaxis in elective hip surgery.

A G Turpie1

  • 1McMaster University, Department of Medicine, Hamilton Civic Hospitals, Ontario, Canada.

Acta Chirurgica Scandinavica. Supplementum
|January 1, 1990
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Treatment of venous thromboembolism in cancer patients with dalteparin for up to 12 months: the DALTECAN Study.

Journal of thrombosis and haemostasis : JTH·2015
Same author

Low-molecular-weight heparin: from the bench to the orthopedic patient.

Orthopedics·2014
Same author

Deep vein thrombosis prophylaxis in the outpatient setting: preventing complications following hospital discharge.

Orthopedics·2014
Same author

Prevention and treatment of venous thromboembolism--International Consensus Statement.

International angiology : a journal of the International Union of Angiology·2014
Same author

The cost-effectiveness of computer-assisted anticoagulant dosage: results from the European Action on Anticoagulation (EAA) multicentre study.

Journal of thrombosis and haemostasis : JTH·2009
Same author

An international multicenter randomized study of computer-assisted oral anticoagulant dosage vs. medical staff dosage.

Journal of thrombosis and haemostasis : JTH·2008
Same journal

Renal perfusion and metabolism in experimental endotoxin shock.

Acta chirurgica Scandinavica. Supplementum·1991
Same journal

Changing the smoking habit and its influence on the management of vascular disease.

Acta chirurgica Scandinavica. Supplementum·1990
Same journal

What is the actual need for vascular surgery and how do we obtain the required resources?

Acta chirurgica Scandinavica. Supplementum·1990
Same journal

The benefits of proximal and distal vascular reconstruction as a one-stage procedure.

Acta chirurgica Scandinavica. Supplementum·1990
Same journal

In situ or reversed vein bypass for lower limb revascularization?

Acta chirurgica Scandinavica. Supplementum·1990
Same journal

Is femoropopliteal bypass surgery indicated for the treatment of intermittent claudication?

Acta chirurgica Scandinavica. Supplementum·1990
See all related articles

Post-operative enoxaparin effectively prevents deep vein thrombosis (DVT) in hip replacement patients. This prophylaxis significantly reduced DVT incidence compared to placebo, demonstrating a favorable safety profile.

Area of Science:

  • Orthopedic Surgery
  • Pharmacology
  • Vascular Medicine

Background:

  • Deep vein thrombosis (DVT) is a significant risk following major orthopedic procedures like hip replacement.
  • Effective prophylaxis is crucial to mitigate the morbidity and mortality associated with DVT.

Purpose of the Study:

  • To evaluate the efficacy and safety of enoxaparin for preventing DVT in patients undergoing elective hip surgery.
  • To compare enoxaparin prophylaxis with placebo in this patient population.

Main Methods:

  • A randomized, double-blind, placebo-controlled trial was conducted.
  • Enoxaparin (30 mg subcutaneously twice daily) was administered post-operatively for 14 days.
  • Incidence of DVT and hemorrhagic complications were recorded.

Related Experiment Videos

Main Results:

  • Deep vein thrombosis occurred in 12% of the enoxaparin group versus 42% in the placebo group (p = 0.0007).
  • Proximal vein thrombosis was significantly lower in the enoxaparin group (4% vs. 20%, p = 0.014).
  • Hemorrhagic complications were similar between groups (two patients each).

Conclusions:

  • Fixed-dose, post-operative enoxaparin is effective in preventing DVT after elective hip replacement.
  • Enoxaparin demonstrates a safe and effective profile for DVT prophylaxis in this surgical context.