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Related Concept Videos

Cirrhosis II: Pathophysiology01:24

Cirrhosis II: Pathophysiology

Cirrhosis is a progressive chronic liver injury caused by prolonged inflammation, excessive fibrotic remodeling, and impaired regeneration. Over time, repeated hepatic insults disrupt the liver’s architecture and function, leading to reduced blood flow, impaired bile drainage, and diminished metabolic capacity.Pathophysiology of cirrhosisCirrhosis arises from three main responses to chronic liver damage: inflammation, immune activation, and hepatocyte death. These processes lead to structural...
Chronic Pancreatitis II: Pathophysiology01:21

Chronic Pancreatitis II: Pathophysiology

Chronic pancreatitis is a progressive and irreversible inflammation of the pancreas, most often caused by long-term alcohol abuse, but it can also be related to ductal obstruction, smoking, or genetic factors.Chronic pancreatitis occurs when the pancreas is repeatedly exposed to harmful agents like alcohol, smoking, ductal obstruction, or genetic predisposition. These factors lead to the release of toxic metabolites and inflammatory cytokines, sustaining chronic inflammation in the pancreatic...
Cirrhosis I: Introduction01:23

Cirrhosis I: Introduction

Cirrhosis is a chronic, irreversible liver disease characterized by the widespread replacement of healthy liver tissue with fibrotic scar tissue and the formation of regenerative nodules.Etiology of cirrhosisCirrhosis results from sustained liver injury that triggers progressive fibrosis and structural remodeling. The underlying causes are diverse, encompassing common and less frequent clinical conditions. Regardless of the origin, all causes lead to chronic inflammation, hepatocyte loss, and...
Acute Pancreatitis II: Clinical Manifestations and Management01:30

Acute Pancreatitis II: Clinical Manifestations and Management

Acute pancreatitis presents a complex medical emergency characterized by rapid onset inflammation of the pancreas, demanding timely diagnosis and management to prevent complications. The condition primarily manifests through severe upper abdominal pain that often radiates to the back. This pain intensifies following the consumption of fatty foods. Accompanying symptoms such as nausea, vomiting, abdominal distention, fever, dyspnea, cyanosis, and jaundice can vary in intensity but significantly...
Portal Hypertension01:22

Portal Hypertension

Portal hypertension is an increase in blood pressure within the portal venous system. Normally, this pressure is less than 5 mmHg. It is considered clinically significant when it rises above 10 mmHg. At this threshold, complications from altered blood flow and venous congestion emerge.EtiologyPortal hypertension arises from conditions that impede blood flow through the liver. The most common cause is cirrhosis, in which chronic liver injury leads to fibrotic scarring. This fibrosis narrows or...
Cholecystitis01:20

Cholecystitis

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Related Experiment Video

Updated: Jun 21, 2026

Bile Duct Ligation in Mice: Induction of Inflammatory Liver Injury and Fibrosis by Obstructive Cholestasis
08:56

Bile Duct Ligation in Mice: Induction of Inflammatory Liver Injury and Fibrosis by Obstructive Cholestasis

Published on: February 10, 2015

[Post-traumatic secondary biliary cirrhosis].

Elias Shlomo1, Lalazar Gadi, Shouval Daniel

  • 1Department of Medicine, Hebrew University-Hadassah Medical Center, Jerusalem, Israel. shlomoe@ekmd.huji.ac.il

Harefuah
|July 28, 2009
PubMed
Summary
This summary is machine-generated.

Critically ill patients can develop secondary biliary cirrhosis, a rare liver condition, after severe trauma and intensive care unit (ICU) stays. This case report highlights the unusual progression to cirrhosis in a young patient without prior liver disease.

Related Experiment Videos

Last Updated: Jun 21, 2026

Bile Duct Ligation in Mice: Induction of Inflammatory Liver Injury and Fibrosis by Obstructive Cholestasis
08:56

Bile Duct Ligation in Mice: Induction of Inflammatory Liver Injury and Fibrosis by Obstructive Cholestasis

Published on: February 10, 2015

Area of Science:

  • Critical care medicine
  • Hepatology
  • Pathology

Background:

  • Critically ill patients in the intensive care unit (ICU) face risks of liver injury from various factors.
  • Liver dysfunction in ICU patients is often transient, but severe cases can lead to long-term complications.

Observation:

  • This case report details a young patient with no prior liver disease who developed secondary biliary cirrhosis after a severe motor vehicle accident and ICU admission.
  • Recent literature suggests a link between severe, life-threatening injuries requiring prolonged ICU stays (mechanical ventilation, vasopressors) and the development of sclerosing cholangitis.

Findings:

  • The described cholangiopathy presents with gradually increasing cholestatic enzymes and bilirubin, with only moderate aminotransferase elevation.
  • Cholangiography may reveal multifocal biliary strictures, mimicking primary sclerosing cholangitis, after excluding other causes of cholestasis like bile duct obstruction.
  • This condition is characterized by rapid progression to liver cirrhosis.

Implications:

  • This case underscores the potential for severe, progressive liver disease in critically ill patients following major trauma.
  • Recognizing this specific cholangiopathy is crucial for timely diagnosis and management in ICU survivors.
  • Further research is needed to understand the pathogenesis and develop targeted therapies for ICU-acquired sclerosing cholangitis and cirrhosis.