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Updated: Jun 21, 2026

Drug-Induced Sleep Endoscopy (DISE) with Target Controlled Infusion (TCI) and Bispectral Analysis in Obstructive Sleep Apnea
07:54

Drug-Induced Sleep Endoscopy (DISE) with Target Controlled Infusion (TCI) and Bispectral Analysis in Obstructive Sleep Apnea

Published on: December 6, 2016

[Obstructive sleep apnea syndrome in young infants]

Eran Rosenberg1, Soliman Elkrinawi, Aviv Goldbart

  • 1Department of Pediatrics B, Soroka University Medical Center, Faculty of Health Sciences, Ben-Gurion University, Beer Sheba, Israel.

Harefuah
|July 28, 2009
PubMed

Insights

Obstructive sleep apnea syndrome (OSAS) is prevalent in infants under two, causing increased healthcare use and morbidity. Early diagnosis and treatment of infant OSAS are crucial for preventing negative health outcomes.

Area of Science:

  • Pediatrics
  • Sleep Medicine
  • Respiratory Medicine

Background:

  • Obstructive sleep apnea syndrome (OSAS) is commonly diagnosed in children aged 3-6 years, often due to adenotonsillar hypertrophy.
  • OSAS in children can lead to significant health issues, including neurocognitive, behavioral, growth, and cardiac problems.
  • This study focuses on OSAS in infants younger than 2 years, an understudied demographic.

Purpose of the Study:

  • To determine the clinical and sleep characteristics of OSAS in infants under 2 years old.
  • To evaluate the morbidity and healthcare utilization associated with OSAS in this young population.
  • To assess the impact of early diagnosis and treatment on health outcomes.

Main Methods:

  • A retrospective study involving 35 infants under 2 years with suspected OSAS who underwent polysomnography.
  • A control group of healthy, age, gender, and pediatrician-matched children was included for comparison.
  • Analysis of clinical data, sleep study results (e.g., apnea/hypopnea index), and healthcare utilization records.

Main Results:

  • 33 out of 35 infants were diagnosed with OSAS, with a mean apnea/hypopnea index of 18.7 events/hour.
  • Infants with OSAS showed significantly higher rates of primary care visits, emergency room visits, and hospitalizations compared to controls.
  • OSAS patients had longer hospital stays and received more drug prescriptions; adenoidectomy improved AHI in 13 patients.

Conclusions:

  • OSAS is a significant condition in infants younger than 2 years.
  • Infants with OSAS experience higher morbidity and healthcare utilization than their healthy peers.
  • Prompt diagnosis and intervention for infant OSAS are essential to mitigate associated health risks.
Abstract

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