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Updated: Jun 21, 2026

An Aptamer-based Sensor for Unchelated Gadolinium(III)

An Aptamer-based Sensor for Unchelated Gadolinium(III)

Published on: January 9, 2017

A new gadolinium-based MRI zinc sensor.

Ana C Esqueda¹, Jorge A López, Gabriel Andreu-de-Riquer

¹Departamento de Química, Universidad de Guanajuato, Cerro de la Venada s/n, Guanajuato, Gto., C.P. 36040, México.

Journal of the American Chemical Society

|July 28, 2009

Summary

A new gadolinium (Gd3+)-based MRI sensor, GdL, shows enhanced zinc (Zn2+) detection. The GdL:Zn2+ complex strongly binds to human serum albumin (HSA), significantly increasing MRI signal for potential in vivo zinc imaging.

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Published on: July 21, 2011

Area of Science:

Biomedical Engineering
Medical Imaging
Analytical Chemistry

Background:

Gadolinium (Gd3+)-based agents are crucial for Magnetic Resonance Imaging (MRI) contrast.
Zinc (Zn2+) plays vital roles in biological systems, and its dysregulation is linked to various diseases.
Developing sensitive and specific MRI sensors for biological analytes like Zn2+ remains a challenge.

Purpose of the Study:

To report the properties of a novel Gd3+-based MRI sensor designed for Zn2+ detection.
To investigate the binding characteristics of the sensor with human serum albumin (HSA) and Zn2+.
To evaluate the sensor's potential for in vivo Zn2+ imaging.

Main Methods:

Synthesis and characterization of the novel Gd3+-based sensor (GdL).
Assessment of GdL binding affinity to Zn2+ using established methods (e.g., Kd determination).
Evaluation of the ternary complex (GdL:Zn2+) binding to HSA and its effect on water proton relaxivity using MRI.

Main Results:

The GdL sensor exhibits a strong binding affinity for Zn2+ (Kd = 33.6 nM).
The GdL:Zn2+ complex demonstrates strong binding to HSA, leading to a 3-fold increase in water proton relaxivity.
The sensor detected Zn2+ concentrations as low as 30 microM in the presence of HSA in vitro.

Conclusions:

The novel GdL sensor shows promise for detecting biologically relevant concentrations of free Zn2+.
The strong HSA binding and increased relaxivity of the GdL:Zn2+ complex facilitate sensitive MRI detection.
This Gd3+-based sensor offers potential for non-invasive in vivo imaging of Zn2+ without disrupting biological processes.