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Interrelationships between human immunodeficiency virus and cytomegalovirus
1Department of Microbiology and Immunology, Eastern Virginia Medical School, Norfolk 23501.
Archivum Immunologiae Et Therapiae Experimentalis
|January 1, 1990
Summary
Cytomegalovirus (CMV) frequently infects AIDS patients. These viruses share traits and may interact molecularly, potentially worsening disease in coinfected individuals.
Area of Science:
- Virology
- Immunology
- Infectious Diseases
Background:
- Cytomegalovirus (CMV) is an opportunistic infection prevalent in individuals with Acquired Immunodeficiency Syndrome (AIDS).
- CMV and Human Immunodeficiency Virus (HIV) share characteristics like lymphoid cell infection, latency, sexual transmission, and immunosuppression.
Purpose of the Study:
- To explore the relationship between CMV and HIV in AIDS patients.
- To investigate potential molecular interactions between CMV and HIV.
Main Methods:
- Prevalence studies in AIDS patients.
- Comparative analysis of viral characteristics.
- Molecular interaction studies (e.g., transactivation assays).
Main Results:
- High prevalence of CMV in AIDS patients and those at risk.
- Shared biological features between CMV and HIV.
- Evidence of molecular interaction via transactivation of genes.
Conclusions:
- CMV is a selective opportunistic pathogen in AIDS.
- CMV and HIV may have a unique synergistic relationship.
- Each virus may contribute to the pathogenesis of the other.