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Preparation and characterization of tegafur magnetic thermosensitive liposomes
Zhaowu Zeng1, Xiaoli Wang, Yangde Zhang
1National Hepatobiliary & Enteric Surgery Research Center, Ministry of Health, Central South University, National Key Laboratory of Nanobiological Technology, Institute of Biomedical Engineering of Central South University, Changsha, Hunan, P.R. China.
Abstract:
The purpose was to study the preparation and properties of tegafur magnetic thermosensitive liposomes. The method was to employ an improved chemical coprecipitation method for preparing nano-magnetic particles and a reverse-phase evaporation and ultrasonic method for preparing tegafur magnetic thermosensitive liposomes. The results showed that tegafur magnetic thermosensitive liposomes were prepared successfully. They had comparatively strong magnetism and superparamagnetism, and their temperature showed a linear positive correlation with dosages and the field strength under a current value. The conclusion was that tegafur magnetic thermosensitive liposomes with comparatively small particle size, superparamagnetism and comparatively strong magnetism were prepared successfully.
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