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Quantification of Monocyte Transmigration and Foam Cell Formation from Individuals with Chronic Inflammatory Conditions
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The fate of monocytes in atherosclerosis

G J Randolph1

  • 1Department of Gene and Cell Medicine, and the Immunology Institute, Mount Sinai School of Medicine, New York, NY 10029, USA. gwendalyn.randolph@mssm.edu

Journal of Thrombosis and Haemostasis : JTH
|July 28, 2009
PubMed

Insights

Monocytes are key inflammatory cells in atherosclerosis. Targeting these cells offers potential therapeutic strategies by modulating their phenotype, recruitment, survival, or egress from plaques to resolve inflammation.

Area of Science:

  • Immunology
  • Cardiovascular Biology
  • Pathology

Background:

  • Monocytes are the primary inflammatory cells infiltrating atherosclerotic plaques.
  • Monocyte recruitment into plaques is a critical driver of atherosclerosis progression.

Purpose of the Study:

  • To discuss potential therapeutic intervention points targeting monocytes in atherosclerosis.
  • To explore strategies for modulating monocyte phenotype, recruitment, survival, and egress.

Main Methods:

  • Review of existing literature on monocyte function in atherosclerosis.
  • Discussion of potential therapeutic targets and strategies.

Main Results:

  • Monocyte involvement in atherosclerosis is multifaceted, offering several intervention points.
  • Targeting monocyte subpopulations, recruitment, survival, and egress are all viable therapeutic avenues.

Conclusions:

  • Modulating monocyte behavior presents a promising strategy for treating atherosclerosis.
  • Further research into specific interventions targeting monocytes is warranted.

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