Related Experiment Video
Updated: Jun 21, 2026

Probing the Limits of Egg Recognition Using Egg Rejection Experiments Along Phenotypic Gradients
Published on: August 22, 2018
Empirical and theoretical phenotypic discrimination
K E Brummel-Ziedins1, T Orfeo, F R Rosendaal
1Department of Biochemistry, University of Vermont, Colchester, VT 05446, USA. Kathleen.brummel@uvm.edu
Abstract:
We have developed an integrated approach that combines empirical and computational methodologies to define an individual's thrombin phenotype. We have evaluated the process of thrombin generation in healthy individuals and individuals with defined pathologies in order to develop general criteria relevant to assess an individual's propensity for hemorrhage or thrombosis. Three complementary hypotheses have emerged from our work: (i) compensation by the ensemble of other coagulation proteins in individuals with specific factor deficiencies can 'normalize' an individual's thrombin generation process and represents a rationale for their unexpected phenotype; (ii) individuals with clinically unremarkable factor levels may present thrombin generation profiles typical of individuals with hemostatic complications; and (iii) in some hemostatic disorders a specific pattern of expression of a small ensemble of coagulation factors may be sufficient to explain the overall phenotype.
Related Concept Videos
Background and Environment Affect Phenotype
An example of how genetic background affects phenotype can be seen in horses. The Extension gene in horses is responsible for their coat color. A wild-type gene (EE) produces black pigment in the coat, while a mutant gene (ee) produces red pigment. A...
Epistasis Analysis
Types of Selection
Stereotypes, Prejudice, and Discrimination
Epistasis
Frequency-dependent Selection

