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10:26
A Multicenter MRI Protocol for the Evaluation and Quantification of Deep Vein Thrombosis
Published on: June 2, 2015
What happens after venous thromboembolism?
1Department of Haematology, Addenbrooke's NHS Trust, Cambridge, UK. trevor.baglin@addenbrookes.nhs.uk
Journal of Thrombosis and Haemostasis : JTH
|July 28, 2009
Summary
Venous thromboembolism (VTE), including deep vein thrombosis (DVT) and pulmonary embolism (PE), shares similar recurrence risks. The pattern of VTE recurrence may be predetermined, influencing long-term anticoagulant therapy decisions.
Area of Science:
- Cardiovascular Medicine
- Hematology
- Thrombosis Research
Background:
- Venous thromboembolism (VTE) encompasses deep vein thrombosis (DVT) and pulmonary embolism (PE).
- VTE affects 1.5 per 1000 person-years, with a 5% lifetime incidence.
- Recurrence risk for DVT and PE is similar, but the pattern often mirrors the initial event.
Purpose of the Study:
- To explore the predetermined nature of VTE phenotypic expression.
- To consider implications for long-term anticoagulant therapy.
- To identify factors influencing VTE pattern and embolization.
Main Methods:
- Literature review and analysis of existing epidemiological data on VTE incidence and recurrence.
- Examination of the relationship between initial VTE presentation and subsequent events.
- Review of factors associated with VTE pattern, such as Factor V Leiden mutation.
Main Results:
- A significant overlap exists between symptomatic DVT and asymptomatic PE, and vice versa.
- The pattern of VTE recurrence tends to reflect the initial presentation.
- Previous PE is associated with the highest risk of fatal PE.
Conclusions:
- DVT and PE are manifestations of the same pathology, with potentially predetermined phenotypic expression.
- Understanding VTE patterns is crucial for tailoring long-term anticoagulant strategies.
- Thrombin generation kinetics and fibrinolytic response may influence clot structure and embolization risk.
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