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Related Concept Videos

Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
Inflammation01:38

Inflammation

Overview
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
Peripheral Artery Disease I: Introduction01:30

Peripheral Artery Disease I: Introduction

Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
Chronic Inflammation: Introduction01:12

Chronic Inflammation: Introduction

Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...

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Related Experiment Video

Updated: Jun 21, 2026

A Human Ex Vivo Atherosclerotic Plaque Model to Study Lesion Biology
05:51

A Human Ex Vivo Atherosclerotic Plaque Model to Study Lesion Biology

Published on: May 6, 2014

Inflammatory mechanisms in atherosclerosis.

G K Hansson1

  • 1Karolinska Institutet, Center for Molecular Medicine L8:03, Department of Medicine, Karolinska University Hospital, Stockholm, Sweden. Goran.Hansson@ki.se

Journal of Thrombosis and Haemostasis : JTH
|July 28, 2009
PubMed
Summary
This summary is machine-generated.

Atherosclerosis is an inflammatory disease where LDL accumulation triggers immune responses, leading to plaque growth and potential rupture. Anti-inflammatory therapies show promise for managing this condition.

Related Experiment Videos

Last Updated: Jun 21, 2026

A Human Ex Vivo Atherosclerotic Plaque Model to Study Lesion Biology
05:51

A Human Ex Vivo Atherosclerotic Plaque Model to Study Lesion Biology

Published on: May 6, 2014

Area of Science:

  • Cardiovascular Biology
  • Immunology
  • Pathology

Background:

  • Atherosclerosis is a primary cause of myocardial infarction, stroke, and ischemic gangrene.
  • The disease process involves the accumulation of low-density lipoprotein (LDL) in the arterial intima.
  • Endothelial activation and immune cell recruitment are key early events.

Purpose of the Study:

  • To elucidate the inflammatory mechanisms underlying atherosclerosis.
  • To highlight the role of immune cells and their mediators in plaque development.
  • To explore the potential of anti-inflammatory strategies for disease management.

Main Methods:

  • Review of inflammatory pathways involved in LDL accumulation and endothelial activation.
  • Analysis of monocyte-derived macrophage and T cell responses within atherosclerotic lesions.
  • Examination of cytokine and protease release contributing to plaque progression.

Main Results:

  • LDL accumulation activates the endothelium, promoting leukocyte adhesion molecule and chemokine expression.
  • Macrophages and T cells within lesions release pro-inflammatory cytokines, proteases, and vasoactive molecules.
  • Intensified inflammation can lead to plaque rupture, thrombus formation, and ischemic events.

Conclusions:

  • Atherosclerosis is fundamentally an inflammatory disease driven by immune cell interactions.
  • Inflammatory markers are valuable for monitoring disease progression.
  • Targeting inflammatory pathways represents a potential therapeutic approach for atherosclerosis.