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Related Concept Videos

Hormones and Bone Tissue01:17

Hormones and Bone Tissue

The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Functions of Thyroid Hormones01:18

Functions of Thyroid Hormones

The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
Synthesis and Regulation of Thyroid Hormones01:20

Synthesis and Regulation of Thyroid Hormones

Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The iodine is then...
Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
Skeleton and Calcium Homeostasis01:21

Skeleton and Calcium Homeostasis

Calcium is not only the most abundant mineral in bone but also the most abundant mineral in the human body. Calcium ions are needed for bone mineralization, tooth health, heart rate regulation and strength of contraction, blood coagulation, the contraction of smooth and skeletal muscle cells, and the regulation of nerve impulse conduction. The average calcium level in the blood is about 10 mg/dL. When the body cannot maintain this level, a person will experience hypo or hypercalcemia.
Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...

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Related Experiment Videos

Thyroid-stimulating hormone, thyroid hormones, and bone loss.

Mone Zaidi1, Terry F Davies, Alberta Zallone

  • 1Mount Sinai Bone Program, Mount Sinai School of Medicine, New York, NY 10029, USA. mone.zaidi@mssm.edu

Current Osteoporosis Reports
|July 28, 2009
PubMed
Summary
This summary is machine-generated.

Thyroid-stimulating hormone (TSH) directly suppresses bone remodeling. Reduced TSH signaling contributes to osteoporosis in thyrotoxicosis, suggesting TSH and its receptor as potential drug targets for bone loss.

Related Experiment Videos

Area of Science:

  • Endocrinology
  • Bone Biology
  • Metabolic Diseases

Background:

  • Thyrotoxicosis is linked to high-turnover osteoporosis, with bone loss primarily from accelerated resorption.
  • Elevated thyroid hormones were considered the sole cause of bone loss in thyrotoxicosis.
  • Thyroid hormone receptors play a role in bone remodeling, but TSH's independent action remained unclear.

Purpose of the Study:

  • To investigate the direct role of thyroid-stimulating hormone (TSH) in bone remodeling.
  • To determine if reduced TSH signaling contributes to osteoporosis in hyperthyroid states.

Main Methods:

  • Studied mice lacking thyroid hormone receptors alpha and beta.
  • Analyzed TSH receptor null mice to assess TSH signaling in bone loss.
  • Examined the direct effect of TSH on bone remodeling.

Main Results:

  • TSH was found to directly suppress bone remodeling.
  • TSH receptor null mice exhibited significant bone loss.
  • Reduced TSH signaling is implicated in hyperthyroid osteoporosis.

Conclusions:

  • TSH directly influences bone remodeling, independent of thyroid hormones.
  • Decreased TSH signaling contributes to the bone loss seen in thyrotoxicosis.
  • Targeting the TSH receptor may offer a novel therapeutic strategy for osteoporosis.