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Updated: Jul 24, 2026

12:47
Inducing Plasticity of Astrocytic Receptors by Manipulation of Neuronal Firing Rates
Published on: March 21, 2014
The benzodiazepine receptor in cultured astrocytes from genetically epilepsy-prone rats
I Ducis1, L O Norenberg, M D Norenberg
1Laboratory of Neuropathology, University of Miami/Jackson Memorial Hospital, FL.
Brain Research
|October 29, 1990
Abstract:
Peripheral-type benzodiazepine (BZD) receptors were studied in cultured astrocytes derived from genetically epilepsy-prone and control rats. Scatchard analysis of the binding of [3H]Ro 5-4864 to astrocyte homogenates from epilepsy-prone rats showed 38% fewer BZD receptors (Bmax) as compared to controls. No significant change in affinity (Kd) was observed. These findings suggest that the astrocyte peripheral-type BZD receptor may be involved in some forms of epilepsy.

