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Dysbindin modulates brain function during visual processing in children.

A Mechelli1, E Viding, A Kumar

  • 1Department of Psychology, Institute of Psychiatry, King's College London, 103 Denmark Hill, London, UK. a.mechelli@iop.kcl.ac.uk

Neuroimage
|July 28, 2009
PubMed
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Genetic variations in dystrobrevin binding protein 1 (DTNBP1) influence visual processing in children. Carriers of the risk allele show altered occipital cortex function, suggesting a role in neurodevelopmental disorders like schizophrenia.

Area of Science:

  • Neuroscience
  • Genetics
  • Developmental Psychology

Background:

  • Schizophrenia is a neurodevelopmental disorder linked to genetic risk factors impacting brain development.
  • Dystrobrevin binding protein 1 (DTNBP1) is a potential susceptibility gene for schizophrenia, but its precise role in brain function remains unclear.
  • Previous research suggests DTNBP1 may influence visual processing.

Purpose of the Study:

  • To investigate the impact of a specific DTNBP1 genetic variant (rs2619538) on visual processing in healthy children.
  • To determine if carriers of the schizophrenia risk allele exhibit altered occipital cortical function.

Main Methods:

  • Functional Magnetic Resonance Imaging (fMRI) was employed to measure brain activity during a visual matching task in 61 children (aged 10-12).

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  • Participants were genotyped for the DTNBP1 rs2619538 variant.
  • Data analysis utilized statistical parametric mapping with corrected statistical inferences (p<0.05).

    • Main Results:

    • Risk allele carriers demonstrated significantly greater activation in the lingual gyrus, fusiform gyrus, and inferior occipital gyri compared to noncarriers.
    • DTNBP1 genotype explained substantial inter-individual variance in activation within these visual processing regions (14-20%).

    Conclusions:

    • Genetic variation in DTNBP1 is associated with measurable differences in visual processing areas of the brain.
    • These genetic effects on visual function are detectable in young children, supporting DTNBP1's role in early brain development.
    • Findings suggest DTNBP1 influences brain development, potentially modulating schizophrenia vulnerability.