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Reaction of NO with O2-. implications for the action of endothelium-derived relaxing factor (EDRF)
1Institut für Strahlenbiologie, GSF Research Center, Neuherberg, W. Germany.
Free Radical Research Communications
|January 1, 1990
Abstract:
Under physiological pH conditions (pH 7.2-7.4) the rate constant of the reaction NO + O2- yielding peroxonitrite (ONOO-) was determined as k = (3.7 +/- 1.1) x 10(7) M-1 s-1. The decay of peroxonitrite at this pH follows first order kinetics with a rate constant of 1.4 s 1. At alkaline pH peroxonitrite is practically stable. Possible consequences of these reactions for the biological lifetime of EDRF will be discussed.