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Abnormal timing of visual feedback processing in young adults with schizophrenia
Chantal Kemner1, John J Foxe, Judith E Tankink
1Rudolf Magnus Institute of Neuroscience, Utrecht, The Netherlands. C.Kemner@umcutrecht.nl
Neuropsychologia
|July 28, 2009
Summary
Schizophrenia patients show delayed feedback processing in visual perception, not reduced. This timing difference may explain enhanced detail processing and altered visual integration in schizophrenia.
Area of Science:
- Neuroscience
- Cognitive Psychology
- Psychiatry
Background:
- Schizophrenia is linked to visual perceptual deficits, particularly in integrating visual information.
- Impaired visual feedforward processing (P1 ERP component) is noted, but feedback processing roles remain unclear.
- Feedback processing is crucial for stimulus integration, making its role in schizophrenia significant.
Purpose of the Study:
- To investigate atypical recurrent (feedbackward) processing in recent-onset schizophrenia.
- To explore the relationship between feedback processing and visual perception in schizophrenia.
Main Methods:
- Utilized a texture segregation task with event-related brain potential (ERP) measurements.
- Compared 14 young adult males with recent-onset schizophrenia to 17 age- and IQ-matched male controls.
Main Results:
- Schizophrenia group exhibited normal feedbackward processing amplitudes but longer latencies.
- Observed enhanced occipito-temporal activity around 160 ms in schizophrenia, suggesting increased detail processing.
Conclusions:
- First evidence of abnormal timing in feedback activity during visual perception in schizophrenia.
- Hypothesized that delayed feedback processing reflects abnormal structural connectivity, potentially leading to over-processing of stimulus details.
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