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Updated: Jun 21, 2026

High-Resolution Endocardial and Epicardial Optical Mapping in a Sheep Model of Stretch-Induced Atrial Fibrillation
Published on: July 29, 2011
Role of atrial substrate and spatiotemporal organization in atrial fibrillation
Albert M Kim1, Jeffrey E Olgin, Thomas H Everett
1Department of Medicine, University of California, San Francisco, San Francisco, California 94143-1354, USA. Albert.Kim@ucsf.edu
Abstract:
Atrial fibrillation (AF) is a heterogeneous disease that presents in a wide range of clinical scenarios. Correspondingly, a diverse array of large animal models has developed for the study of AF. Different atrial substrate exists in these models, and quantitative analysis of the AF that develops in each case reveals unique characteristics. This article reviews the defining properties of several prominent AF animal models, with a focus on how spatiotemporal organization can discriminate between AF substrates. It addresses how spatiotemporal assessments have been extended to human AF and discusses the insights gained from these new analyses.
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