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Updated: Jun 21, 2026

Surgical Models of Gastroesophageal Reflux with Mice
Published on: August 25, 2015
[Gastroesophageal reflux treatment: from therapeutic abstention to surgery]
1Service de gastroentérologie et nutrition pédiatriques, hôpital Armand-Trousseau, 26 avenue du Dr-Arnold-Netter, Paris cedex 12, France. p.tounian@trs.aphp.fr
Insights
Evidence for treating pediatric gastroesophageal reflux is limited. This review examines treatment options, finding limited data for most interventions but some support for thickened feeding, prokinetics, and proton pump inhibitors.
Area of Science:
- Pediatric Gastroenterology
- Pharmacology
- Clinical Nutrition
Context:
- Gastroesophageal reflux is a common condition in children.
- Current treatment strategies are widely applied but lack robust evidence.
- A critical review of existing literature is needed to guide clinical practice.
Purpose:
- To review and analyze the efficacy of various treatment options for pediatric gastroesophageal reflux.
- To develop an evidence-based treatment strategy for different clinical scenarios.
- To highlight the need for a critical appraisal of current therapeutic approaches.
Summary:
- Scientific evidence supporting dietetic and postural advice for pediatric gastroesophageal reflux is scarce.
- Limited evidence exists for the efficacy of thickened feeding, certain prokinetics, and proton pump inhibitors.
- A proposed treatment strategy integrates available evidence for practical application in pediatric care.
Impact:
- Informs evidence-based clinical decision-making for pediatric gastroesophageal reflux management.
- Identifies research gaps and areas needing further investigation.
- Promotes a more judicious and effective therapeutic approach to a common childhood condition.
Abstract:
Although treatment of gastroesophageal reflux is commonly prescribed in pediatrics, an examination of the scientific literature seems worthy. First, this paper develops the treatment options of gastroesophageal reflux and analyses the different studies aimed at demonstrating their efficacy. Evidence-based data are scant either for dietetic and postural advice or drugs prescriptions. Evidence does exist for thickened feeding, some prokinetics and proton pump inhibitors only. Secondly, a treatment strategy based on these data is proposed according to the different situations in current practice. An appraisal of the therapeutic approach of this frequent and mild child's disease appears necessary.
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