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Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
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Related Experiment Video

Updated: Jun 21, 2026

Trans-vivo Delayed Type Hypersensitivity Assay for Antigen Specific Regulation

Trans-vivo Delayed Type Hypersensitivity Assay for Antigen Specific Regulation

Published on: May 2, 2013

Syphilis-specific immunoglobulin G seroconversion after double-lung transplantation.

Joerg Steinmann¹, Guenther Marggraf, Jan Buer

¹Institute of Medical Microbiology, University Hospital Essen, Essen, Germany. joerg.steinmann@uk-essen.de

The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation

|July 28, 2009

Summary

A lung transplant recipient developed syphilis antibodies due to donor B cells, not active infection. This suggests passive antibody transfer, not active Treponema pallidum transmission, in organ recipients.

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Murine Intrapulmonary Tracheal Transplantation: A Model for Investigating Obliterative Airway Disease After Lung Transplantation

Murine Intrapulmonary Tracheal Transplantation: A Model for Investigating Obliterative Airway Disease After Lung Transplantation

Published on: November 10, 2023

Area of Science:

Infectious disease
Transplant immunology
Serology

Background:

Chronic obstructive pulmonary disease (COPD) management can involve lung transplantation.
Organ donors may have serologic evidence of past infections, including syphilis.
Assessing infection risk in transplant recipients is critical.

Observation:

A patient with end-stage COPD underwent a double-lung transplant.
The donor had serologic markers for past syphilis infection.
The recipient experienced Treponema pallidum-specific IgG seroconversion post-transplant.

Findings:

Recipient IgG antibody titers for Treponema pallidum increased initially after transplantation.
Antibody titers subsequently decreased by Month 3 post-transplantation.
The observed seroconversion is attributed to transmission of immunocompetent B cells from the donor graft.

Implications:

This case highlights the potential for passive antibody transfer of infections like syphilis via organ transplantation.
It suggests that reactive serology in recipients may not always indicate active infection.
Further investigation into B cell-mediated passive immunity in transplantation is warranted.