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Studying Triple Negative Breast Cancer Using Orthotopic Breast Cancer Model
09:29

Studying Triple Negative Breast Cancer Using Orthotopic Breast Cancer Model

Published on: March 20, 2020

Triple-negative breast cancer: novel therapies and new directions

Sumanta Kumar Pal1, Joanne Mortimer

  • 1Division of Genitourinary Malignancies, Department of Medical Oncology & Experimental Therapeutics, City of Hope Comprehensive Cancer Center, Duarte, CA 91010, USA. spal@coh.org

Maturitas
|July 28, 2009
PubMed

Insights

Novel targeted therapies show promise for triple-negative breast cancer (TNBC). Poly(ADP-ribosyl)ation polymerase (PARP) inhibitors and other agents are being investigated for improved treatment outcomes in this aggressive subtype.

Area of Science:

  • Oncology
  • Translational Medicine
  • Genetics

Background:

  • Triple-negative breast cancer (TNBC) represents about 15% of breast cancer cases.
  • TNBC shares characteristics with basal-type and BRCA1-positive breast cancer.
  • Conventional cytotoxic agents show TNBC is chemo-sensitive.

Purpose of the Study:

  • To review novel targeted therapeutic strategies for triple-negative breast cancer.
  • To highlight recent advancements and ongoing research in TNBC treatment.

Main Methods:

  • Review of recent clinical trials and preclinical studies.
  • Focus on targeted agents beyond conventional chemotherapy.

Main Results:

  • Poly(ADP-ribosyl)ation polymerase (PARP) inhibitors (BSI-201, olaparib) show high efficacy in TNBC and BRCA1/2-positive disease.
  • Antiangiogenic agents (bevacizumab, sunitinib) are under investigation.
  • Preclinical data suggest potential activity for heat shock protein 90 (Hsp90) and Src inhibitors.

Conclusions:

  • Targeted therapies, including PARP inhibitors, offer new avenues for TNBC treatment.
  • Ongoing research into antiangiogenic, Hsp90, and Src inhibitors may yield future therapeutic options.

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