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Related Experiment Videos

Medroxyprogesterone induced Cushing's syndrome.

D Learoyd1, A McElduff

  • 1Department of Endocrinology, Royal North Shore Hospital, Sydney, NSW, Australia.

Australian and New Zealand Journal of Medicine
|December 1, 1990
PubMed
Summary

Medroxyprogesterone acetate (MPA) can cause Cushing's syndrome by acting as an exogenous glucocorticoid. Discontinuation of MPA resolved symptoms and normalized hormone levels in a patient.

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Area of Science:

  • Endocrinology
  • Pharmacology

Background:

  • Cushing's syndrome is characterized by excessive cortisol exposure.
  • Medroxyprogesterone acetate (MPA) is a synthetic progestin with potential glucocorticoid activity.

Observation:

  • A 74-year-old female on MPA developed Cushing's syndrome with paradoxical low cortisol and ACTH levels.
  • Impaired response to synthetic ACTH (cosyntropin) was noted.

Findings:

  • Cessation of MPA therapy led to the resolution of cushingoid features.
  • Serum cortisol, plasma ACTH, and ACTH responsiveness normalized after MPA withdrawal.

Implications:

  • MPA can act as an exogenous glucocorticoid, mimicking Cushing's syndrome.
  • Careful monitoring for glucocorticoid side effects is necessary in patients taking MPA.
  • This case highlights a rare presentation of MPA-induced Cushing's syndrome.

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