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Medroxyprogesterone induced Cushing's syndrome
1Department of Endocrinology, Royal North Shore Hospital, Sydney, NSW, Australia.
Australian and New Zealand Journal of Medicine
|December 1, 1990
Abstract:
A 74-year old female taking medroxyprogesterone acetate (MPA) presented with Cushing's syndrome together with low serum cortisol and plasma ACTH and an impaired response to synthetic ACTH (Synacthen, CIBA). When the medroxyprogesterone therapy was ceased the cushingoid features resolved and serum cortisol, ACTH and ACTH responsiveness all returned to normal. The MPA was acting as an exogenous glucocorticoid causing Cushing's syndrome.