Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Pentobarbital blocks the stress-induced decrease in [3H]Ro 5-4864 binding in rat kidney.

R C Drugan1, P V Holmes, A P Stringer

  • 1Schrier Research Laboratory, Department of Psychology, Brown University, Providence, RI 02912.

Brain Research
|December 3, 1990
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Development and Evaluation of a Molecular Diagnostic Method for Rapid Detection of Histoplasma capsulatum var. farciminosum, the Causative Agent of Epizootic Lymphangitis, in Equine Clinical Samples.

Journal of clinical microbiology·2016
Same author

Owner reported diseases of working equids in central Ethiopia.

Equine veterinary journal·2016
Same author

Clinical Research Abstracts of the British Equine Veterinary Association Congress 2015.

Equine veterinary journal·2015
Same author

Host density drives macroparasite abundance across populations of a critically endangered megaherbivore.

Oecologia·2015
Same author

Galanin mediates features of neural and behavioral stress resilience afforded by exercise.

Neuropharmacology·2014
Same author

Prior cold water swim stress alters immobility in the forced swim test and associated activation of serotonergic neurons in the rat dorsal raphe nucleus.

Neuroscience·2013
Same journal

IGFBP3 and UBE2C are associated with protein modification pathways and serve as prognostic markers in glioma.

Brain research·2026
Same journal

Targeting neurodevelopmental miR132-3p promotes neuroprotection and axon regeneration after optic nerve injury in mice.

Brain research·2026
Same journal

Variability in acoustic startle response and prepulse inhibition across adulthood in Fragile X messenger ribonucleoprotein 1 knockout mice.

Brain research·2026
Same journal

Transcriptome-guided modeling reveals insulin-related metabolic dysfunction in SCA3 mouse cerebellum.

Brain research·2026
Same journal

Intranasal stromal cell-derived factor-1α mitigates parkinsonian deficits via dual modulation of neuroinflammation and gut microbiota in MPTP-induced models.

Brain research·2026
Same journal

Emotions, the amygdala, and the right hemisphere.

Brain research·2026
See all related articles

Environmental stress alters peripheral benzodiazepine receptors (PBRs). Central nervous system (CNS) intervention with sodium pentobarbital prevented stress-induced PBR changes in rat kidneys, suggesting supraspinal control.

Area of Science:

  • Neuroscience
  • Pharmacology
  • Stress Physiology

Background:

  • Environmental stress impacts peripheral benzodiazepine receptors (PBRs) binding.
  • The role of the central nervous system (CNS) in stress-induced PBR modifications remains unclear.

Purpose of the Study:

  • To investigate if sodium pentobarbital pretreatment affects stress-induced reductions in renal PBR.

Main Methods:

  • Rats were pretreated with varying doses of sodium pentobarbital (sedative/ataxic and hypnotic).
  • Following pretreatment, rats were exposed to environmental stress.
  • The binding of [3H]Ro 5-4864 to renal PBR was measured.

Main Results:

  • Pretreatment with both sedative/ataxic (20 mg/kg) and hypnotic (60 mg/kg) doses of pentobarbital blocked the stress-induced decrease in [3H]Ro 5-4864 binding to renal PBR.

Related Experiment Videos

  • This indicates that pentobarbital administration mitigated the effects of stress on renal PBR.

    • Conclusions:

    • Higher-order, supraspinal mechanisms are critical in regulating renal PBR responses to stress.
    • The CNS plays a significant role in mediating the physiological adaptations to environmental stressors.