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Related Experiment Video

Updated: Jun 21, 2026

A Primary Neuron Culture System for the Study of Herpes Simplex Virus Latency and Reactivation
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Published on: April 2, 2012

Polyradiculopathy and herpes zoster.

Brandon Claflin1, Milton Thomas, Amy J Wilson

  • 1Department of Physical Medicine and Rehabilitation, Baylor University Medical Center and Baylor Institute of Rehabilitation, Dallas, Texas, USA. brandocl@BaylorHealth.edu

Proceedings (Baylor University. Medical Center)
|July 28, 2009
PubMed
Summary

Shingles (herpes zoster) can rarely cause weakness in multiple nerve roots, a condition called polyradiculopathy. This case highlights the importance of considering shingles in diagnosing lower extremity weakness with dermatomal skin involvement.

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Area of Science:

  • Neurology
  • Infectious Diseases
  • Dermatology

Background:

  • Herpes zoster (shingles) commonly presents with skin eruptions and neuropathic pain.
  • Lower extremity weakness has a broad differential diagnosis.
  • Polyradiculopathy, weakness affecting multiple nerve roots, is an uncommon complication of herpes zoster.

Purpose of the Study:

  • To report a rare case of polyradiculopathy secondary to herpes zoster infection.
  • To emphasize the importance of considering herpes zoster in the differential diagnosis of lower extremity weakness.

Main Methods:

  • Retrospective case review.
  • Clinical history and physical examination.
  • Diagnostic testing.

Main Results:

  • The patient presented with weakness involving more than one nerve root level.
  • Dermatomal involvement was noted.
  • The diagnosis of polyradiculopathy secondary to herpes zoster was established.

Conclusions:

  • While rare, polyradiculopathy is a potential complication of herpes zoster infection.
  • A thorough clinical evaluation, including history, physical examination, and diagnostic testing, is crucial for diagnosing this condition.
  • Early diagnosis and appropriate treatment are essential for managing herpes zoster-induced polyradiculopathy.