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Six-minute walking test in children with ESRD: discrimination validity and construct validity.

Tim Takken1, Raoul Engelbert, Monique van Bergen

  • 1Department of Pediatric Physical Therapy & Exercise Physiology, Wilhelmina Children's Hospital, University Medical Centre Utrecht, The Netherlands. t.takken@umcutrecht.nl

Pediatric Nephrology (Berlin, Germany)
|July 28, 2009
PubMed
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Children with end-stage renal disease (ESRD) demonstrate reduced functional exercise capacity on the six-minute walking test (6MWT). Hematocrit and height are key predictors of 6MWT performance in this population.

Area of Science:

  • Pediatrics
  • Nephrology
  • Exercise Physiology

Background:

  • Functional exercise capacity is crucial for children with end-stage renal disease (ESRD).
  • The six-minute walking test (6MWT) is a practical tool for assessing exercise capacity.
  • Limited data exists on 6MWT performance in pediatric ESRD patients compared to healthy peers.

Purpose of the Study:

  • To compare 6MWT performance in children with ESRD against healthy reference values.
  • To identify predictors of 6MWT performance in pediatric ESRD, including anthropometric, clinical, aerobic, and strength parameters.

Main Methods:

  • Twenty children (mean age 14.1 years) with ESRD undergoing dialysis participated.
  • Standardized anthropometric measurements were recorded.

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  • 6MWT was performed in a 20-m hallway; aerobic capacity (VO2peak, Wpeak, VT) and muscle strength were also assessed.

    • Main Results:

    • Children with ESRD exhibited significantly reduced 6MWT performance (83% of predicted, p < 0.0001).
    • Hematocrit and height were the strongest predictors, explaining 59-60% of the variance in 6MWT performance.
    • 6MWT performance was not associated with VO2peak, muscle strength, or other anthropometric variables.

    Conclusions:

    • The 6MWT is a valuable tool for monitoring clinical status in pediatric ESRD patients.
    • Despite its utility, the 6MWT cannot replace comprehensive fitness assessments like VO2peak or muscle strength testing.