Related Experiment Video

Updated: Jun 21, 2026

Isolation of Pulmonary Artery Smooth Muscle Cells from Neonatal Mice
08:02

Isolation of Pulmonary Artery Smooth Muscle Cells from Neonatal Mice

Published on: October 19, 2013

[Rethinking oxygen therapy for premature infants in terms of oxidative stress]

Chao-Jung Yuan1, Yi-Ming Hua, Tzu-Ying Lee

  • 1Department of Nursing, National Taipei College of Nursing, ROC.

Hu Li Za Zhi the Journal of Nursing
|July 28, 2009
PubMed

Insights

Oxygen therapy is crucial for premature infants but can cause oxidant injury. This review guides neonatal intensive care unit (NICU) nurses on safe oxygen practices to prevent complications and improve infant outcomes.

Area of Science:

  • Neonatal medicine and intensive care
  • Pediatric respiratory and critical care

Context:

  • Oxygen therapy is a standard intervention for premature infants in the neonatal intensive care unit (NICU).
  • Premature infants possess underdeveloped antioxidant defenses, increasing susceptibility to oxidant injury.
  • Several common complications in premature infants, including retinopathy, chronic lung disease, intraventricular hemorrhage, and periventricular leukomalacia, are linked to secondary oxidant injuries.

Purpose:

  • To explore the complex relationship between oxygen administration and the development of complications in premature infants.
  • To provide NICU nurses with updated concepts and best practices for oxygen therapy.
  • To minimize oxygen-related complications and enhance the health and quality of life for premature infants.

Summary:

  • This article examines how oxygen therapy, while essential, can contribute to oxidant-related morbidities in premature neonates.
  • It details common neonatal complications potentially exacerbated by oxidative stress from oxygen exposure.
  • Evidence-based guidelines for appropriate oxygen use in the NICU are discussed to mitigate risks.

Impact:

  • Improved understanding of oxygen's dual role in neonatal care, balancing therapeutic benefits with potential harm.
  • Empowerment of NICU nurses with knowledge to implement safer oxygen protocols.
  • Potential reduction in the incidence and severity of major neonatal morbidities, leading to better long-term outcomes for premature infants.

More Related Videos

A Swine Model of Neonatal Asphyxia10:36

A Swine Model of Neonatal Asphyxia

Published on: October 11, 2011

Related Concept Videos

Treatment for Pulmonary Arterial Hypertension: Oxygen Therapy for Respiratory Failure01:16

Treatment for Pulmonary Arterial Hypertension: Oxygen Therapy for Respiratory Failure

Oxygen therapy has emerged as a significant tool in enhancing the quality of life for patients suffering from pulmonary arterial hypertension (PAH). While this therapy has principally been studied on patients with significant hypoxemia, this therapeutic approach helps prevent potential organ damage and can be administered in the comfort of one's home.
Oxygen therapy is vital in increasing and maintaining blood oxygen levels in PAH patients. As a result, it aids in reducing fatigue, improving...
Oxygen Requirements and Growth Patterns01:29

Oxygen Requirements and Growth Patterns

Microorganisms exhibit diverse oxygen requirements and growth patterns driven by their metabolic strategies and environmental adaptations. Oxygen, while essential for many organisms, can also be toxic under certain conditions, shaping how microorganisms grow and survive.Oxygen Requirements of MicroorganismsMicroorganisms are classified based on their ability to use or tolerate oxygen:● Obligate aerobes like Mycobacterium tuberculosis need oxygen for energy production, as it serves as the...
Respiratory Assessment: Purpose and Indications01:19

Respiratory Assessment: Purpose and Indications

Respiratory assessment is a cornerstone of nursing assessments, crucial for the early detection of patient deterioration. This evaluation transcends routine procedures, representing a critical skill nurses must master to ensure optimal patient care.
Objectives and Importance:
The primary goal of respiratory assessment is to evaluate patients at early risk of clinical deterioration. Since respiratory distress often precedes other signs of declining health, breathing patterns and sounds become a...
Oxygen Transport in the Blood01:27

Oxygen Transport in the Blood

Hemoglobin (Hb) is a crucial molecule in the human body, consisting of four polypeptide chains, each bound to an iron-containing heme group. This unique structure enables hemoglobin to bind to oxygen, with each molecule capable of combining with four molecules of oxygen, leading to rapid and reversible oxygen loading. When fully loaded with oxygen, it is called oxyhemoglobin, while hemoglobin that has released oxygen is called reduced hemoglobin or deoxyhemoglobin. As hemoglobin binds oxygen,...
Physiological Control of Respiration01:23

Physiological Control of Respiration

Introduction
Breathing, a seemingly passive process, is regulated by the respiratory center in the brainstem. This center coordinates the involuntary control of respirations, which means it occurs without conscious effort, ensuring a smooth and uninterrupted pattern.
Regulation of Ventilation
The body maintains ventilation by monitoring levels of carbon dioxide (CO2), oxygen (O2), and hydrogen ion concentration (pH) in the arterial blood. Among these factors, the level of CO2 plays a crucial...
Respiration and Gaseous Exchange01:20

Respiration and Gaseous Exchange

The intricate interplay between the cardiovascular and respiratory systems is crucial for efficiently transporting respiratory gases throughout the body. Let us explore the cardiovascular system's multifaceted functions, emphasizing its pivotal role in gas exchange.
Respiration involves the exchange of gases, especially oxygen (O2) and carbon dioxide (CO2), between the alveoli and body cells, a process facilitated by blood circulation. As a result, the cardiovascular system, which involves the...