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Updated: Jun 21, 2026

Multidisciplinary Approach to Obesity Management: A Case Report
Published on: May 30, 2025
Obesity is associated with a more severe overactive bladder disease state that is effectively treated with once-daily
Michael B Chancellor1, Michael G Oefelein, Sandip Vasavada
1Department of Urology, William Beaumont Hospital, Detroit, Michigan, USA.
Aims:
Obesity is an established risk factor for urinary incontinence, yet no information exists as to the efficacy of antimuscarinic agents in this population. The goal of this study is to examine the efficacy of once daily trospium chloride (Sanctura) XR in overweight and obese patients with the overactive bladder syndrome.
Methods:
The primary and secondary end-points of the 1,165 study subjects from the integrated trospium chloride XR pivotal trials were stratified by World Health Organization (WHO) obesity levels I and II.
Results:
Obesity (WHO level I, II criteria) was associated with a more severe baseline OAB disease state (P < 0.01). Trospium chloride XR was more effective than placebo at reducing the primary endpoints (toilet voids, UUI, P < 0.0001) and at improving the secondary end-points (percent patients continent and urgency severity, P < 0.0001) for WHO obesity levels I and II.
Conclusions:
Obesity is associated with a more severe OAB disease state. Once daily trospium chloride XR is efficacious in the obese patient with the OAB syndrome.
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