Clinical and angiographic profile of the diabetic patient: one-year follow-up
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Published on: September 22, 2020
Marco Serrão1, Andreia Pereira, Nuno Santos
1Departamento de Cardiologia Médico-Cirúrgica, Hospital Central do Funchal, Funchal, Portugal. serrao.marco@gmail.com
Insights
Diabetic patients undergoing percutaneous coronary intervention face higher risks of adverse cardiac events and mortality. Aggressive treatment in diabetes mellitus still results in poor long-term outcomes.
Area of Science:
- Cardiology
- Endocrinology
- Vascular Medicine
Background:
- Diabetes mellitus significantly increases cardiovascular morbidity and mortality.
- Diabetic patients often present with complex coronary artery disease.
- Percutaneous coronary intervention (PCI) is a common revascularization strategy.
Purpose of the Study:
- To describe the clinical and angiographic profile of diabetic patients undergoing PCI.
- To evaluate the one-year outcomes of diabetic patients after PCI compared to non-diabetic patients.
Main Methods:
- Retrospective study of 769 patients (241 diabetic, 528 non-diabetic).
- Analysis of clinical, demographic, angiographic, and angioplasty data.
- Assessment of composite endpoint of adverse cardiac events and total mortality at one year.
Main Results:
- Diabetic patients had higher prevalence of cardiovascular risk factors and complex lesions.
- More stents, including drug-eluting stents, were implanted in diabetic patients.
- Diabetic patients experienced significantly higher one-year adverse cardiac events (23.6% vs. 15.9%) and mortality (5.8% vs. 2.3%).
Conclusions:
- Diabetes mellitus is associated with adverse long-term prognosis despite aggressive PCI and medical management.
- Diabetic patients undergoing PCI require careful monitoring and potentially tailored therapeutic strategies.
Unlabelled:
Diabetes mellitus is associated with significant cardiovascular morbidity and mortality. The authors describe the clinical and angiographic profile of a diabetic population undergoing percutaneous coronary intervention, with one-year follow-up.
Methods:
We retrospectively studied 769 patients (241 diabetic [D] and 528 nondiabetic [ND]) in terms of clinical and demographic characteristics, angiography and angioplasty data, and medical therapy, and analyzed the composite endpoint of adverse cardiac events at one month and one year.
Results:
Women, older mean age, hypertension, dyslipidemia, previous stroke and renal insufficiency were more prevalent in the D group. It also had more patients with left ventricular dysfunction, multivessel disease and complex coronary lesions. A significantly higher number of stents per patient and more drug-eluting stents were implanted in this group. Occurrence of the composite endpoint at one-year follow-up was significantly higher in diabetic patients (D = 23.6% vs. ND = 15.9%; p = 0.012), and one-year total mortality was 5.8% in the D group vs. 2.3% in the ND group (p = 0.012).
Conclusion:
Even with aggressive percutaneous and pharmacological management, diabetes mellitus still has an adverse long-term prognosis.
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