[New strategies in tissue engineering--Tissue Inducible Biomaterials]

Tissue engineering has typically been such an approach that relies on isolation and culture of primary cells (seed cells), seeding these cells onto porous scaffolds, maintaining under static or flow condition (Bioreactor) for a period of time prior to implantation. However, experience of almost thirty years in this research field tells us that the typical tissue engineering approach relies on autologous cells, expensive and time consuming. Tissue engineering products do not function very well and are difficult to get FDA approval. In recent years biomaterial scientists created a new concept "Tissue Inducible Biomaterials". The concept is based on designing of microstructure of scaffolds, chemical modification and incorporation of bioactive molecule to scaffolds. Thus the scaffolds gain tissue induction activity, and will facilitate tissue regeneration and repair in vivo. The concepts of "In Vivo Tissue Engineering" and "Tissue Inducible Biomaterials" are been recognized by the Society, and are becoming the new approaches in tissue engineering: Based on the research of the related references within the past three years, the present paper summarized the strategy of tissue inducible biomaterials.