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Phenylethanoid glycosides from Lantana fucata with in vitro anti-inflammatory activity
Lisieux de Santana Julião1, Anna Lisa Piccinelli, Stefania Marzocco
1Programa de Biotecnologia Vegetal, Faculdade de Farmacia, Universidade Federal do Rio de Janeiro, CCS, Bl. A, 2 andar, Ilha do Fundao, 21.941-590, Rio de Janeiro, RJ, Brazil.
Abstract:
A phytochemical analysis of Lantana fucata dried leaves led to the isolation of three new phenylethanoid glycosides, fucatosides A-C, along with parvifloroside A and six known methoxyflavones. Their structures were established by NMR and ESIMS experiments. In vitro assays showed that the alcoholic extract and fucatoside C have significant anti-inflammatory effects, inhibiting NO release in the LPS-induced J774.A1 murine macrophage cell line.
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