Related Experiment Video
Updated: Jun 21, 2026

Hyperglycemic Clamp and Hypoglycemic Clamp in Conscious Mice
Published on: January 26, 2024
Maintaining physiological state for exceptional survival: What is the normal level of blood glucose and does it
Anatoli I Yashin1, Svetlana V Ukraintseva, Konstantin G Arbeev
1Center for Population Health and Aging, Duke University, Durham, NC 27708-0408, USA. aiy@duke.edu
Abstract:
The levels of blood glucose (BG) in humans tend to increase with age deviating from the norm specified for the young adults. Such elevation is often considered as a factor contributing to an increase in risks of disease and death. The proper use of intervention strategies coping with or preventing consequences of BG elevation requires understanding the roles of external forces and intrinsic senescence in this process. To address these issues, we performed analyses of longitudinal data on BG collected in the Framingham Heart Study using methods of descriptive statistics and statistical modeling. The approach allows us to separate effects of persistent external disturbances from "normal" aging-related changes due to the senescence process. We found that the BG level corresponding to the lowest mortality risk tends to increase with age. The changes in the shape of the mortality risk with age indicate the aging-related decline in resistance to stresses affecting the BG level. The results show that analyzing longitudinal data using advanced methods may substantially increase our knowledge on factors and mechanisms responsible for aging-related changes in humans.
More Related Videos
08:01A Method for Manipulating Blood Glucose and Measuring Resulting Changes in Cognitive Accessibility of Target Stimuli
Published on: August 12, 2016
12:59Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People
Published on: July 5, 2017
Related Concept Videos
Hypoglycemia and Glucagon
Glucose Homeostasis: Regulation of Blood Glucose
During fasting, when blood glucose levels are low, the pancreas secretes glucagon. it...
Hypoglycemia
Hyperglycemia
Homeostatic Imbalance
However, sometimes these feedback loops fail,...
Hormones Regulating Blood Glucose
In addition to accelerating glucose uptake and utilization, insulin has...