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Updated: Jun 21, 2026
14:20
Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?
Published on: June 13, 2014
Discovery of novel selective HER-2 sheddase inhibitors through optimization of P1 moiety
Yun-Long Li1, Eric Shi, David Burns
1Incyte Corporation, Experimental Station-E336, Route 141 and Henry Clay Road, Wilmington, DE 19880, USA. yunli@incyte.com
Bioorganic & Medicinal Chemistry Letters
|July 29, 2009
Abstract:
A novel series of carbamates was discovered as potent and selective HER-2 sheddase inhibitors. Significant enhancement in potency and selectivity was achieved through attenuating the P1 moiety, which was conventionally believed to be exposed to solvent.
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