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Generation and Expansion of Primary, Malignant Pleural Mesothelioma Tumor Lines

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Malignant peritoneal mesothelioma: a multicenter study on 81 cases.

V de Pangher Manzini¹, L Recchia¹, M Cafferata²

¹Division of Medical Oncology, Department of Internal Medicine and Oncology, Monfalcone Hospital, Monfalcone.

Annals of Oncology : Official Journal of the European Society for Medical Oncology

|July 29, 2009

Summary

Malignant peritoneal mesothelioma (MPM) is a rare cancer with challenging diagnosis and poor prognosis. This study highlights its varied presentations, frequent association with thrombocytosis, and a median survival of 13 months.

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Area of Science:

Oncology
Pathology

Background:

Malignant peritoneal mesothelioma (MPM) is a rare malignancy.
Characterized by diagnostic challenges, diverse presentations, and poor prognosis.

Purpose of the Study:

To delineate the history and characteristics of malignant peritoneal mesothelioma (MPM).

Main Methods:

Retrospective analysis of 81 MPM patients from 14 Italian institutions (1982-2007).
Evaluation of clinical presentation, diagnostic imaging, cytology, laparoscopy/laparotomy findings, and associated conditions.
Analysis of treatment modalities (surgery, chemotherapy) and survival data.

Main Results:

Common symptoms included ascites, abdominal pain, and weight loss. Diagnostic signs included ascites and peritoneal thickening.
Peritoneal fluid cytology was positive in 31/61 cases. Thrombocytosis was observed in 59 cases.
Median survival was 13 months. Ascites, fever, and vomiting were significant presentation variables, with vomiting being significant in multivariate analysis.

Conclusions:

MPM presents diversely, often with thrombocytosis and sometimes with other tumors.
Survival and diagnosis timelines vary among MPM subtypes.
The overall prognosis for malignant peritoneal mesothelioma remains poor.