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Diffusion Tensor Magnetic Resonance Imaging in Chronic Spinal Cord Compression

Diffusion Tensor Magnetic Resonance Imaging in Chronic Spinal Cord Compression

Published on: May 7, 2019

Hodgkin disease with spinal cord compression.

Vineeta Gupta¹, Arvind Srivastava, Baldev Bhatia

¹Department of Pediatrics, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India. vineetaguptabhu@gmail.com

Journal of Pediatric Hematology/Oncology

|July 29, 2009

Summary

Neurologic complications like spinal cord compression are rare in pediatric Hodgkin disease. This study highlights two pediatric cases presenting with neurological signs, emphasizing the importance of considering Hodgkin lymphoma in differential diagnoses.

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Area of Science:

Pediatric Oncology
Neurology
Hematology

Background:

Hodgkin disease typically affects lymph nodes.
Spinal cord or root compression is an uncommon complication, usually associated with advanced disease stages.

Observation:

Two pediatric patients with Hodgkin disease presented with distinct neurological symptoms.
One patient exhibited paravertebral masses and thoracic vertebral involvement, initially mistaken for spinal tuberculosis.
The second patient developed paraplegia and neurogenic bladder/bowel dysfunction due to an epidural mass and vertebral collapse.

Findings:

Lymph node biopsies confirmed Hodgkin disease, mixed cellularity, in both pediatric cases.
The presenting neurological signs were directly linked to the extent of the disease involvement in the spine.

Implications:

This report underscores the necessity of including Hodgkin lymphoma in the differential diagnosis for pediatric patients presenting with spinal or neurological deficits.
Early recognition and appropriate treatment, including chemotherapy and radiotherapy, are crucial for managing these rare presentations of pediatric Hodgkin disease.