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Miller-Fisher syndrome and pontine abnormalities on MRI: a case report
M Giroud1, C Mousson, J M Chalopin
1Service de Neurologie, Hôpital Général, Dijon, France.
Abstract:
The authors report a patient with Miller-Fisher syndrome in whom MRI of the brain stem showed increased signal density on T2 sequence anterior to the fourth ventricle, on the right and the left. The authors discuss the relation between these MRI abnormalities and some clinical features of the syndrome. The authors believe that the cardinal features of Miller-Fisher syndrome are due to peripheral nervous system dysfunction, but that this does not preclude a possible central nervous system involvement.
Insights
Miller-Fisher syndrome, a rare neurological disorder, can involve central nervous system abnormalities. Brainstem MRI in one patient revealed T2 hyperintensities, suggesting potential CNS involvement alongside peripheral dysfunction.
Area of Science:
- Neurology
- Neuroimaging
Background:
- Miller-Fisher syndrome (MFS) is a rare variant of Guillain-Barré syndrome.
- MFS is typically characterized by ophthalmoplegia, ataxia, and areflexia.
Observation:
- This report details a case of Miller-Fisher syndrome with specific neuroimaging findings.
- Magnetic Resonance Imaging (MRI) of the brainstem revealed increased signal density on T2-weighted sequences.
Findings:
- The observed MRI abnormalities were located anterior to the fourth ventricle, bilaterally.
- These findings suggest potential central nervous system involvement in Miller-Fisher syndrome.
Implications:
- The study discusses the relationship between these MRI abnormalities and the clinical presentation of MFS.
- While MFS is primarily considered a peripheral nervous system disorder, this case highlights the possibility of concurrent central nervous system involvement.