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Osteoporosis in chronic liver disease: a case-control study
Ghizlane Wariaghli1, Aziza Mounach, Lahsen Achemlal
1Rheumatology and Physical Rehabilitation Department, Military Hospital Mohammed V, PO Box: 1018, Rabat, Morocco. wariaghli@yahoo.com
Rheumatology International
|July 29, 2009
Summary
Osteoporosis is a common complication in chronic liver disease (CLD) patients, occurring at twice the rate seen in the general population. Female sex, cholestasis, and lower body weight/height are key risk factors for developing this bone condition in CLD.
Area of Science:
- Hepatology
- Endocrinology
- Orthopedics
Background:
- Osteoporosis is an emerging complication in patients suffering from chronic liver disease (CLD).
- Understanding the prevalence and specific risk factors for osteoporosis in CLD is crucial for patient management.
Purpose of the Study:
- To determine the prevalence of osteoporosis in patients with CLD (primary biliary cirrhosis, chronic viral hepatitis B or C).
- To identify risk factors associated with osteoporosis in CLD patients compared to age- and sex-matched controls.
Main Methods:
- Dual-energy X-ray absorptiometry (DXA) was used to assess bone mineral density at the lumbar spine and total hip.
- Vertebral fractures were identified using densitometric morphometry (vertebral fracture assessment).
- Serum markers of bone turnover (parathyroid hormone, osteocalcin, C-telopeptides) were analyzed.
Main Results:
- The prevalence of osteoporosis in CLD patients was 45.3%, significantly higher than in controls (19.6%).
- Risk factors identified include female sex, cholestasis, lower weight, and lower height; age, menopausal status, and disease stage were not significant.
- Vertebral fractures were present in 5.3% of CLD patients.
Conclusions:
- Osteoporosis is a significant complication of chronic liver disease.
- Cholestasis, female sex, and lower body weight/height are identified as key risk factors for osteoporosis in the CLD population.
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