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Updated: Jun 21, 2026
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Published on: June 26, 2013
Surface feature-guided mapping of cerebral metabolic changes in cognitively normal and mildly impaired elderly
Liana G Apostolova1, Paul M Thompson, Steve A Rogers
1Department of Neurology, David Geffen School of Medicine, University of California-Los Angeles, 10911 Weyburn Avenue, Los Angeles, CA 90095, USA. lapostolova@mednet.ucla.edu
Purpose:
The aim of this study was to investigate the longitudinal positron emission tomography (PET) metabolic changes in the elderly.
Procedures:
Nineteen nondemented subjects (mean Mini-Mental Status Examination 29.4 +/- 0.7 SD) underwent two detailed neuropsychological evaluations and resting 2-deoxy-2-[F-18]fluoro-D: -glucose (FDG)-PET scan (interval 21.7 +/- 3.7 months), baseline structural 3T magnetic resonance (MR) imaging, and apolipoprotein E4 genotyping. Cortical PET metabolic changes were analyzed in 3-D using the cortical pattern matching technique.
Results:
Baseline vs. follow-up whole-group comparison revealed significant metabolic decline bilaterally in the posterior temporal, parietal, and occipital lobes and the left lateral frontal cortex. The declining group demonstrated 10-15% decline in bilateral posterior cingulate/precuneus, posterior temporal, parietal, and occipital cortices. The cognitively stable group showed 2.5-5% similarly distributed decline. ApoE4-positive individuals underwent 5-15% metabolic decline in the posterior association cortices.
Conclusions:
Using 3-D surface-based MR-guided FDG-PET mapping, significant metabolic changes were seen in five posterior and the left lateral frontal regions. The changes were more pronounced for the declining relative to the cognitively stable group.
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