Related Experiment Video
Updated: Jun 21, 2026

An Integrated Approach for Microprotein Identification and Sequence Analysis
Published on: July 12, 2022
NMR assignment of S836: a de novo protein from a designed superfamily
Abigail Go1, Seho Kim, Michael Hecht
1Department of Chemistry, Princeton University, NJ 08544, USA.
Abstract:
Libraries of de novo proteins provide an opportunity to explore the structural potential of biological macromolecules that have not been biased by billions of years of evolutionary selection. Characterization of individual members of such libraries provides insight into the diversity of structure and dynamics accessible to nascent protein superfamilies in the absence of evolutionary optimization. Here we report the backbone and side chain chemical shifts of protein S836 from a superfamily of designed 4-helix bundles.
More Related Videos
05:08Application of I TASSER, trRosetta, UCSF Chimera, HADDOCK server, and HEX loria for De Novo and In Silico Design of Proteins
Published on: July 8, 2025
08:04Identification and Classification of Position-specific GABAA Receptor Subunit Missense Variants for Their Role In Hippocampal Pyramidal Neurons
Published on: June 6, 2025
Related Concept Videos
Protein Families
Protein Families
Exon Recombination
Exon shuffling follows “splice frame rules.” Each exon has three reading...
Conserved Binding Sites
Binding sites are often located in large pockets, and if their location on a protein’s surface is unknown, it can be predicted using various approaches. The energetic method computationally analyses the...
Gene Families
Occasionally these regions can be adapted to take on new roles within the organism, becoming novel genes...