Related Experiment Video
Updated: Jun 21, 2026

CD Spectroscopy to Study DNA-Protein Interactions
Published on: February 10, 2022
NMR assignment and secondary structure of human growth arrest and DNA damage alpha protein (Gadd45 alpha)
Ricardo Sánchez1, David Pantoja-Uceda, Daniel Torres
1Structural Biology Unit, CIC Biogune, Parque Tecnológico de Bizkaia, Ed. 800, Derio, 48160, Spain.
Abstract:
Gadd45 alpha is a predominantly nuclear protein encoded by a DNA-damage-inducible gene which is transcriptionally regulated by the tumor suppressor p53. The interactions of Gadd45 alpha with several other proteins play a central role in DNA repair, cell cycle control and apoptosis. The NMR assignments of human Gadd45 alpha protein reported here provide the basis for further characterization of these interactions.
Related Concept Videos
DNA Damage can Stall the Cell Cycle
DNA Damage Can Stall the Cell Cycle
Mismatch Repair
Bacterial Protein Maturation

