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Intracranial dural histiocytosis
Natale Russo1, Felice Giangaspero, Mario Rojas Beccaglia
1Department of Neurological Sciences, Neurosurgery, Umberto I Hospital - Sapienza University, Rome, Italy. natale-russo@libero.it
British Journal of Neurosurgery
|July 29, 2009
Summary
Rosai-Dorfman disease, a lymphomatous disorder, rarely presents as isolated intracranial lesions. This study highlights two unique cases, informing diagnosis and treatment for neurosurgeons and neuroradiologists.
Area of Science:
- Neuropathology
- Neuroradiology
- Oncology
Background:
- Rosai-Dorfman disease is typically a benign lymphomatous disorder affecting lymph nodes and solid organs.
- Neurological involvement, particularly isolated intracranial lesions, is exceptionally rare.
Observation:
- The presented cases involve intracranial Rosai-Dorfman lesions without systemic lymphadenopathy.
- One patient had a solitary dural lesion, while the other presented with multiple intracranial lesions.
Findings:
- Intracranial Rosai-Dorfman lesions can radiologically mimic meningiomas, but some possess distinct features.
- The classification of isolated intracranial Rosai-Dorfman lesions as Rosai-Dorfman disease versus intradural histiocytosis remains a subject of debate.
Implications:
- Optimal treatment strategies for intracranial Rosai-Dorfman lesions are controversial, with surgery and radiotherapy being common approaches.
- These case reports offer valuable insights for neuroradiologists and neurosurgeons managing rare intracranial histiocytic disorders.
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