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Updated: Jun 21, 2026
09:56
Toxoplasma gondii Cyst Wall Formation in Activated Bone Marrow-derived Macrophages and Bradyzoite Conditions
Published on: August 12, 2010
[Toxoplasmosis after immunosuppressive therapy--our experience]
Z Rusináková1, L Raida, E Faber
1Hemato-onkologická klinika Fakultní nemocnice, University Palackého Olomouc, Czech Republic. zuzana.rusinakova@fnol.cz
Klinicka Mikrobiologie a Infekcni Lekarstvi
|July 29, 2009
Summary
Toxoplasmosis poses a significant risk to immunocompromised patients, particularly after stem cell transplantation. Early diagnosis and treatment are crucial for survival, despite diagnostic challenges.
Area of Science:
- Infectious Diseases
- Hematology
- Immunology
Background:
- Toxoplasmosis is a parasitic infection with severe outcomes in immunocompromised individuals.
- It presents risks for patients with prolonged lymphopenia or on immunosuppressive therapy.
Observation:
- Three cases of toxoplasmosis were observed post-allogeneic HSCT (2.6%) and one post-autologous HSCT (0.3%).
- Clinical manifestations included neurological deficits, cerebral salt-wasting syndrome, and respiratory infections.
Findings:
- Diagnosis combined clinical symptoms with PCR and CT scan results.
- Treatment involved pyrimethamine, clindamycin, co-trimoxazole, and folic acid.
- Three out of four patients survived; one died before treatment initiation.
Implications:
- Increased use of potent immunosuppressive agents heightens toxoplasmosis risk post-HSCT.
- Variable presentation and diagnostic hurdles necessitate improved detection strategies.
- Prompt diagnosis and treatment are vital for improving patient outcomes in HSCT recipients.
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