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Updated: Jun 21, 2026

In Vitro Resident Memory CD8 T Cell Differentiation Using Epithelial Organoid-T Cell Co-culture System
Published on: February 3, 2026
Organization and maintenance of immunological memory by stroma niches
Koji Tokoyoda1, Sandra Zehentmeier, Hyun-Dong Chang
1Deutsches Rheumaforschungszentrum Berlin, Wissenschaftsgemeinschaft Leibniz, Charitéplatz, Berlin, Germany.
Abstract:
Immunological memory is still one of the enigmas of modern immunology. We poorly understand the generation of memory cells from their precursors, the lifestyle of memory cells or their maintenance, reactivation and termination. Here, we discuss the recent evidence suggesting that memory plasma cells, as defined in this review, and memory Th cells are maintained in the bone marrow, resting (in terms of proliferation) in survival niches organized by dedicated stroma cells, which control the homeostasis of immunological memory.
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