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Related Concept Videos

Sanger Sequencing01:57

Sanger Sequencing

DNA sequencing is a fundamental technique that is routinely used in the biological sciences. This method can be applied to a range of questions at different scales - from the sequencing of a cloned DNA fragment or the study of a mutation in a gene up to whole-genome sequencing. However, despite the widespread use of sequencing today, it was not until 1977 that Fredrick Sanger and his collaborators developed the chain-termination method to decode DNA sequences. It relies on the separation of a...

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Related Experiment Video

Updated: Jun 21, 2026

Solution-Processed, Surface-Engineered, Polycrystalline CdSe-SnSe Exhibiting Low Thermal Conductivity
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Solution-Processed, Surface-Engineered, Polycrystalline CdSe-SnSe Exhibiting Low Thermal Conductivity

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Recent developments in selenium research.

D Taylor1, C Dalton, A Hall

  • 1Biomedical Research Centre, Faculty of Health and Wellbeing, Sheffield Hallam University, Howard Street, Sheffield S1 1WB.

British Journal of Biomedical Science
|July 30, 2009
PubMed
Summary
This summary is machine-generated.

Selenium, an essential element, plays crucial roles in human health, including antioxidant activity and thyroid hormone metabolism. Recent research highlights its anticancer properties and interactions with sulfur.

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Area of Science:

  • Biochemistry
  • Nutritional Science
  • Molecular Biology

Background:

  • Selenium is an essential trace element with established roles in antioxidant defense and thyroid hormone metabolism.
  • Recent advancements have elucidated selenium's biochemical functions through studies on selenoproteome gene expression and the selenocysteine synthetic pathway.
  • While 25 human selenium-containing proteins are known, the functions of several remain uncharacterized.

Purpose of the Study:

  • To review recent findings on selenium metabolism, gene expression, and its interaction with sulfur.
  • To explore the emerging evidence for selenium's anticancer properties.
  • To consolidate current understanding of selenium's biochemical roles and its implications in disease.

Main Methods:

  • Literature review of recent biochemical and molecular studies on selenium.
  • Analysis of research on selenoprotein functions and pathways.
  • Examination of studies investigating selenium-sulfur interactions and anticancer effects.

Main Results:

  • Established roles of key selenoproteins (glutathione peroxidases, thioredoxin reductases, iodothyronine deiodinases) in antioxidant activity and thyroid hormone metabolism.
  • Identification of 25 selenium-containing proteins in humans, with ongoing research into their functions.
  • Demonstrated effectiveness of selenium compounds in animal models for cancer prevention, sparking renewed interest.

Conclusions:

  • Selenium's biochemical functions are increasingly understood, particularly its roles in antioxidant defense and thyroid hormone regulation.
  • Further research is needed to fully elucidate the functions of all identified selenoproteins.
  • The interaction between selenium and sulfur, along with selenium's anticancer potential, are promising areas for future investigation in disease prevention and treatment.