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An electronic practice-based network for observational comparative effectiveness research.

Wilson D Pace1, Maribel Cifuentes, Robert J Valuck

  • 1University of Colorado Denver, School of Medicine, Aurora, Colorado 80045-0508, USA. wilson.pace@ucdenver.edu

Annals of Internal Medicine
|July 30, 2009
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Summary
This summary is machine-generated.

The Distributed Ambulatory Research in Therapeutics Network (DARTNet) uses linked electronic health records to study prescription medication effectiveness. This federated network provides crucial clinical insights beyond traditional databases for better comparative effectiveness research.

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Area of Science:

  • Health Informatics
  • Comparative Effectiveness Research
  • Real-World Evidence

Background:

  • Traditional research databases lack critical clinical data for comparative effectiveness.
  • Electronic health records (EHRs) offer a richer data source for understanding treatment outcomes.
  • The Distributed Ambulatory Research in Therapeutics Network (DARTNet) was established to address these limitations.

Purpose of the Study:

  • To leverage a federated network of EHR data for comparative effectiveness research.
  • To gain new insights into the effectiveness of prescription medications and medical devices.
  • To demonstrate the utility of DARTNet for studying oral diabetes medications.

Main Methods:

  • Established a federated network (DARTNet) linking EHR, laboratory, imaging, and administrative data from 8 organizations.
  • Included data from over 500 clinicians and 400,000 patients.
  • Focused on comparative effectiveness of oral diabetes medications.

Main Results:

  • DARTNet successfully linked diverse clinical and administrative data.
  • The network provided new insights into the comparative effectiveness of oral diabetes medications.
  • Demonstrated the potential for DARTNet to expand effectiveness research.

Conclusions:

  • Federated EHR networks like DARTNet are valuable for comparative effectiveness research.
  • DARTNet offers a robust platform for generating real-world evidence on therapeutic interventions.
  • The network is poised for expansion to address broader research questions.