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Related Concept Videos

Anticoagulant Drugs: Low-Molecular-Weight Heparins01:30

Anticoagulant Drugs: Low-Molecular-Weight Heparins

Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
Venous Thrombosis III: Interprofessional Care01:29

Venous Thrombosis III: Interprofessional Care

Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
Anticoagulant Drugs: Vitamin K Antagonists and Direct Oral Anticoagulants01:18

Anticoagulant Drugs: Vitamin K Antagonists and Direct Oral Anticoagulants

Oral anticoagulants are vital tools in preventing and treating blood clotting disorders. This diverse class of medications can be categorized as vitamin K antagonists, exemplified by warfarin, and direct thrombin inhibitors (DTIs), such as dabigatran, as well as factor Xa inhibitors, including rivaroxaban.
Warfarin, a prominent vitamin K antagonist family member, exerts its effect by inhibiting the enzyme VKORC1 (vitamin K epoxide reductase complex 1). By hindering this enzyme, warfarin...
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
Quality Assurance01:19

Quality Assurance

Quality assurance is the overarching term used to describe the activities employed to ensure the proper performance of a system. These activities can be classified into three categories: quality control, quality assessment, and internal corrective measures. Typically, these activities work cyclically: quality control is performed before and during the analysis, while quality assessment occurs during and after the investigation. Internal corrective measures are implemented based on the findings...

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Related Experiment Video

Updated: Jun 21, 2026

Point-Of-Care Ultrasound Screening for Proximal Lower Extremity Deep Venous Thrombosis
06:45

Point-Of-Care Ultrasound Screening for Proximal Lower Extremity Deep Venous Thrombosis

Published on: February 10, 2023

Lupus anticoagulant: case-based external quality assessment.

A M H P van den Besselaar1, K M J Devreese, P G de Groot

  • 1Department of Thrombosis and Haemostasis, Leiden University Medical Centre, PO Box 9600, 2300 RC Leiden, The Netherlands. a.m.h.p.van_den_besselaar@lumc.nl

Journal of Clinical Pathology
|July 30, 2009
PubMed
Summary
This summary is machine-generated.

This study developed a case history model for external quality assessment (EQA) in blood coagulation testing. While useful educationally, the model showed varied laboratory performance in lupus anticoagulant testing.

Related Experiment Videos

Last Updated: Jun 21, 2026

Point-Of-Care Ultrasound Screening for Proximal Lower Extremity Deep Venous Thrombosis
06:45

Point-Of-Care Ultrasound Screening for Proximal Lower Extremity Deep Venous Thrombosis

Published on: February 10, 2023

Area of Science:

  • Clinical Chemistry
  • Hematology
  • Laboratory Medicine

Background:

  • External Quality Assessment (EQA) schemes are crucial for maintaining laboratory testing quality.
  • Developing effective case-based EQA models enhances postanalytical evaluation in diagnostic testing.

Observation:

  • A Dutch EQA scheme for blood coagulation testing utilized a patient case history with lupus erythematosus.
  • Participants received a freeze-dried plasma sample and were asked for test results, interpretation, and further testing suggestions.

Findings:

  • The response rate was 65%, with only 27% performing lupus anticoagulant tests and 32% conducting mixing studies.
  • Interpretations of results were heterogeneous; 54% suggested lupus anticoagulant, but 23% offered no interpretation.
  • Few participants adhered to standardized protocols for lupus anticoagulant identification.

Implications:

  • Case-based EQA serves as a valuable postanalytical educational tool for clinical laboratories.
  • Limitations include sample volume, freeze-dried matrix differences, and sample preparation time lag.
  • Improvements in EQA design are needed to enhance standardization and interpretation consistency in coagulation testing.