[The hormonal mechanisms of the programming and regulation of liver function differentiation by sex]

Crucial role of androgens and estrogens in programming and regulation of the sex-dependent expression of a specific estrogen-binding protein, androgenous and estrogenous receptors and corticosteroid-binding globulin, was shown. Both types of the sex steroids effects were shown to be realized in the hepatocytes through respective hormonal receptors. The realization of physiological effects of the sex hormones demands the participation of STH as a permissive factor. Some theoretical and practical aspects of the sex differentiation of the liver functions, are discussed.